Linking with Meaning: Ontological Hypertext for Scholars

The links in ontological hypermedia are defined according to the relationships between real-world objects. An ontology that models the significant objects in a scholar’s world can be used toward producing a consistently interlinked research literature. Currently the papers that are available online are mainly divided between subject- and publisher-specific archives, with little or no interoperability. This paper addresses the issue of ontological interlinking, presenting two experimental systems whose hypertext links embody ontologies based on the activities of researchers and scholars

Building a Bijou Digital Archive

This presentation relates the experience of building a small open access archive of digitised documents. I start by looking back at my ten years experience as a developer working with the EPrints digital repository platform - this experience was the foundation for my first approach which used EPrints as the basis for the archive. I then move forward to identify the strengths and weaknesses of this approach, ultimately leading to my decision to migrate the digital archive to an alternative platform in order to provide a richer user experience

Supporting the 'Sharing Institution' - Practical Steps Towards a More Open Teaching and Learning Culture

4th International Conference on Open RepositoriesThis presentation was part of the session : Conference PresentationsDate: 2009-05-19 03:00 PM – 04:30 PMInstitutional repositories for research output have developed progressively over the last few years. Although a primary motivation is Open Access both institutional and academic needs must also be met in order to foster this spirit effectively. There is now a greater emphasis on creating a more open culture for teaching and learning and institutions are again beginning to play their part more readily. On a larger scale, there are pioneering global examples of courses being preserved and complex learning materials being deposited in national and international databases. But what does fostering a more open culture in the practice of teaching mean for the institution itself and its academics? The virtual learning environment has given greater opportunities for effective administration of courses but in other ways it has had the opposite effect on sharing and re-use. There is potential for institutional solutions which are complementary to the global landscape. In this paper we report on the practical experiences and issues met, in setting up a institutional resource, EdShare, as a vehicle for sharing educational materials more easily in a multi-disciplinary institution. With constructive feedback from faculty, within the EdSpace project, EdShare has migrated into a more visual, web 2.0 style, resource with a flexible deposit process promoting 'micro-sharing'. It now offers a range of sharing options to support the teaching workflow in an encouraging atmosphere. Other features will support the growing emphasis on multidisciplinary teaching and collaboration - both internally and externally.JIS

Effect of angiotensin-converting enzyme inhibitor and angiotensin receptor blocker initiation on organ support-free days in patients hospitalized with COVID-19

IMPORTANCE Overactivation of the renin-angiotensin system (RAS) may contribute to poor clinical outcomes in patients with COVID-19. Objective To determine whether angiotensin-converting enzyme (ACE) inhibitor or angiotensin receptor blocker (ARB) initiation improves outcomes in patients hospitalized for COVID-19. DESIGN, SETTING, AND PARTICIPANTS In an ongoing, adaptive platform randomized clinical trial, 721 critically ill and 58 non–critically ill hospitalized adults were randomized to receive an RAS inhibitor or control between March 16, 2021, and February 25, 2022, at 69 sites in 7 countries (final follow-up on June 1, 2022). INTERVENTIONS Patients were randomized to receive open-label initiation of an ACE inhibitor (n = 257), ARB (n = 248), ARB in combination with DMX-200 (a chemokine receptor-2 inhibitor; n = 10), or no RAS inhibitor (control; n = 264) for up to 10 days. MAIN OUTCOMES AND MEASURES The primary outcome was organ support–free days, a composite of hospital survival and days alive without cardiovascular or respiratory organ support through 21 days. The primary analysis was a bayesian cumulative logistic model. Odds ratios (ORs) greater than 1 represent improved outcomes. RESULTS On February 25, 2022, enrollment was discontinued due to safety concerns. Among 679 critically ill patients with available primary outcome data, the median age was 56 years and 239 participants (35.2%) were women. Median (IQR) organ support–free days among critically ill patients was 10 (–1 to 16) in the ACE inhibitor group (n = 231), 8 (–1 to 17) in the ARB group (n = 217), and 12 (0 to 17) in the control group (n = 231) (median adjusted odds ratios of 0.77 [95% bayesian credible interval, 0.58-1.06] for improvement for ACE inhibitor and 0.76 [95% credible interval, 0.56-1.05] for ARB compared with control). The posterior probabilities that ACE inhibitors and ARBs worsened organ support–free days compared with control were 94.9% and 95.4%, respectively. Hospital survival occurred in 166 of 231 critically ill participants (71.9%) in the ACE inhibitor group, 152 of 217 (70.0%) in the ARB group, and 182 of 231 (78.8%) in the control group (posterior probabilities that ACE inhibitor and ARB worsened hospital survival compared with control were 95.3% and 98.1%, respectively). CONCLUSIONS AND RELEVANCE In this trial, among critically ill adults with COVID-19, initiation of an ACE inhibitor or ARB did not improve, and likely worsened, clinical outcomes. TRIAL REGISTRATION ClinicalTrials.gov Identifier: NCT0273570

tranScriptorium : computer aided, crowd sourced transcription of hand written text (for repositories?)

Over the past 10+ years significant investment has been made by various European cultural heritage organisations in digitising historical collections of handwritten documents. The output of these digitisation projects may end up in a repository improving access to document images. Can this access be further enhanced? The Transcriptorium project is a European Commission FP7 funded project (2013-2015) that brings together a suite of tools for the purpose of computer aided transcription and enhancement of digitized handwritten material. These software tools include those for document image analysis (DIA) developed by National Centre for Scientific Research (Greece), handwritten text recognition (HTR) developed by the Universitat Politecnica de Valencia (Spain) and natural language models (NLM) developed by Institute of Dutch Lexicology, Universiteit Leiden (Netherlands). As the project required that these tools be available to other systems they have been developed to operate as software services. The project included the development of a desktop application (University of Innsbruck, Austria) and a crowd-sourcing platform (University College London and University of London Computer Centre, UK) that use the DIA, HTR and NLM outputs to arrive at computer aided transcription solutions, designed with the aim of improving efficiency and reducing cost of the transcription of handwritten documents

Research data download process for extended EPrints/Arkivum integration

<p>Mock up of research data download process as part of the EPrints/Arkivum integration used for Research Data Management (Tim Miles-Board, University Of London Computing Centre).</p

Workflows and Flowcharts for report "RDM workflows and integrations for HEIs using hosted services"

<p>Diagrams and flowcharts used in the report "RDM workflows and integrations for HEIs using hosted services" Matthew Addis. DOI: dx.doi.org/10.6084/m9.figshare.1476832</p> <p>The upload and download process for extended EPrints/Arkivum integration (mockups) are by Tim Miles-Board at the University of London Computing Centre (ULCC).   The other diagrams/flowcharts are by Matthew addis, Arkivum.</p

Research data upload process for extended EPrints/Arkivum integration

<p>Mock up of research data upload process as part of the EPrints/Arkivum integration used for Research Data Management (Tim Miles-Board, University Of London Computing Centre).</p